Novaluron 氟酰脲, 双苯氟脲

双苯氟脲

中文名：双苯氟脲
英文名：Novaluron
别名：N-[[3-氯-4-[1,1,2-三氟-2-(三氟甲氧基)乙氧基]苯基]氨基甲酰基]-2,6-双氟苯甲酰胺;双苯氟脲/敌草胺 /氟酰脲
CAS ：116714-46-6
分子式：C17H9ClF8N2O4
分子量：492.7

用途
用于防治水果，蔬菜，棉花，玉米等多种作物的鳞翅目，鞘翅目，半翅目和双翅目幼虫，粉虱等虫。

美国批准 MAI的双苯氟脲
MAI 公司用于棉花 、梨果和马铃薯的3个含双苯氟脲杀虫剂已在美国获得批准，这是昆虫生长调节剂 自2001年在温室观赏植 物上获得批准以来，
首次在美国食用作物上获得登记 。
其中获批准的两种乳油产品分别为：Rimon(双苯氟脲10％)用于马铃薯；Diamond(双苯氟脲10％)用于棉花。7．5％的WDG也以商品名Diamond出售，用于梨果。这些产品将按照独家销售协议，由康普顿／有利来路公司销售。Diamond在棉花上的推荐用量为6～14盎司／英亩(415～970g／L)，在梨果上的推荐用量为1．1～4．4盎司／英亩(1．2～4．9g／L)，Rimon在马铃薯上的推荐用量为9～12盎司／英亩。Diamond和Rimon作为有机磷杀虫剂的替代物加速在美国的登记。
目前，双苯氟脲已在49个国家登记，在40多个国家销售，包括巴西、阿根廷、韩国、哥伦比亚、墨西哥、印度、罗马尼亚、波兰、土耳其和以
色列。2004年第一季度销售额为800万美元，去年同期为200万美元；2003年全球销售额为1840万美元。据MAI预计，该成分的年销售额饱和值可达5000万美元。

novaluron
Insecticide
IRAC 15; benzoylurea

NOMENCLATURE
Common name novaluron (BSI, pa E-ISO)
IUPAC name (?-1-[3-chloro-4-(1,1,2-trifluoro-2-trifluoromethoxyethoxy)phenyl]-3-(2,6-difluorobenzoyl)urea
Chemical Abstracts name (?-N-[[[3-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)ethoxy]phenyl]amino]carbonyl]-2,6-difluorobenzamide
CAS RN [116714-46-6] Development codes GR 572 (Agrimont); MCW-275 (Makhteshim-Agan); SB-7242 (SDS Biotech KK)

PHYSICAL CHEMISTRY
Composition Tech. is 96%. Mol. wt. 492.7 M.f. C17H9ClF8N2O4 Form Solid. M.p. 176.5-178 °C V.p. 1.6 ´ 10-2 mPa (25 °C) (OECD 104, EEC A8) KOW logP = 4.3 (OECD 107, EEC A4) Henry 2 Pa m3 mol-1 (calc.) S.g./density 1.56 (22 °C) Solubility In water 3 mg/l (25 °C) (OECD 105, EEC A6). Soluble in organic solvents. F.p. 202 °C (closed cup) (EEC A9, ASTM E502-84 and ASTM D 32786-82)

COMMERCIALISATION
History Developed by Isagro and subsequently sold to Makhteshim Chemical Works. Patents US 4980376

APPLICATIONS
Biochemistry Chitin synthesis inhibitor, affecting moulting. Mode of action Absorbed mainly by ingestion but shows some contact activity. Causes abnormal endocuticular deposition and abortive moulting. Effective against larvae, but also has a toxic effect on eggs of some species and in some cases reduces fecundity. Uses Under development by Makhteshim Chemical Works for control of Lepidoptera (Spodoptera spp., Plutella xylostella, Cydia spp., etc), Coleoptera (Leptinotarsa decemlineata), Diptera, whitefly, and leaf miners, in cotton, potatoes, citrus, top fruit, vegetables, and maize (I. Ishaaya et al., Proc. Br. Crop Prot. Conf. - Pests Dis., 1996, 3, 1013). Formulation types EC; SC. Selected products: 'Rimon' (Makhteshim-Agan)

OTHER PRODUCTS
'Galaxy' (Makhteshim-Agan); 'Pedestal' (Makhteshim-Agan, Crompton)

MAMMALIAN TOXICOLOGY
Oral Acute oral LD50 for rats >5000 mg/kg. Skin and eye Acute percutaneous LD50 for rats >2000 mg/kg. Not irritating to eyes and skin (rabbits). Not a skin sensitiser (guinea pigs). Inhalation LC50 (4 h) for rats >5.15 mg/l air. NOEL (2 y) for rats 1.1 mg/kg b.w. daily.

ECOTOXICOLOGY
Birds Acute oral LD50 for mallard ducks >2000 mg/kg. Dietary LC50 (5 d) for bobwhite quail and mallard ducks >5200 ppm. Fish LC50 (96 h) for rainbow trout and bluegill sunfish >1 mg/l. Daphnia LC50 (48 h) 0.259 mg/l. Algae Non-toxic. Bees LC50 (oral and contact) >100 mg/bee. Worms Non-toxic. Other beneficial spp. Non-toxic.

ENVIRONMENTAL FATE
Animals The major route of elimination was via the faeces. Plants In potatoes and apples, a.i. remains unchanged. Soil/Environment DT50 (aerobic) 68.5-75.5 d (sandy loam and loamy sand soils). Strongly adsorbed to soil, Koc 6650-11 813.