Metobenzuron 甲氧苯草隆

甲氧苯草隆

CAS:登录号：111578-32-6
英文名称：metobenzuron;
化学名称：（±）-1-甲氧基-3-（4-（2-甲氧基-2，4，4-三甲基色满-7-基氧）苯基）-1-甲基脲；(±)-1-(methoxy-2,4,4-trimethylchroman-7-yloxy)phenyl)-1-methylurea;
分子式：C22H28N2O5
分子量：400.5
结构式：

理化性质：白色粉末状固体，密度1.5136（20℃），熔点101.0～102.5℃，蒸气压2.47×10-3 pa，25℃水中溶解度0.4mg/l.

毒性：LD50(mg/kg)：大鼠急性经口大于10000，兔急性经皮大于1000。对兔皮肤无刺傲，对兔眼睛有中度刺嫩．无致突变性、无致畸性。

作用特点及杀草谱：酰亚胺类除草剂 ，光合作用抑制剂．其活性是阿特拉津、利谷隆的20～100倍。甲氧苯草隆主要用于玉米田苗后防除重要的阔叶杂草，如苋属杂草、苍耳、曼陀螺、藜属杂草、龙葵、豚草、牵牛等。对阿特拉津产生抗性的杂草也良好的防除效果。施用剂量为125～250g/ha。若与2，4-滴混用，不仅可扩大杀草谱，还具有显著的增效作用。

生产方法：以间苯二酚为起始原料，首先与丙酮反应，再经醚化、加成、还原制得中问体取代的苯胺，然后制成异氰酸酯与盐酸羟胺反应，最后经烷基化即得．
生产情况：日本三菱化成公司开发生产。国内尚没有生产企业，也没有登记信息。

metobenzuron
Herbicide
urea

NOMENCLATURE
Common name metobenzuron (BSI, pa E-ISO)
IUPAC name (?-1-methoxy-3-[4-(2-methoxy-2,4,4-trimethylchroman-7-yloxy)phenyl]-1-methylurea
Chemical Abstracts name (?-N'-[4-[(3,4-dihydro-2-methoxy-2,4,4-trimethyl-2H-1-benzopyran-7-yl)oxy]phenyl]-N-methoxy-N-methylurea
CAS RN [111578-32-6] Development codes UMP-488 (Mitsui Petrochemical)

PHYSICAL CHEMISTRY
Mol. wt. 400.5 M.f. C22H28N2O5 Form White powder. M.p. 101.0-102.5 ºC Solubility In water 0.4 mg/l (25 ºC).

COMMERCIALISATION
History Reported by T. Morimoto et al. (Proc. Br. Crop Prot. Conf. - Weeds, 1993, 1, 67). Introduced by Mitsui Petrochemical Industries Ltd (now Mitsui Chemicals Inc.). Manufacturers Mitsui

APPLICATIONS
Biochemistry Inhibitor of photosynthesis. Uses Selective post-emergence herbicide for control of a wide range of broad-leaved weeds, including triazine-resistant weeds, in maize. Application rates 125-250 g/ha. Compatibility Combination with 2,4-D increases efficacy and widens the weed spectrum.

MAMMALIAN TOXICOLOGY
Oral Acute oral LD50 for rats and mice >10 000 mg/kg. Skin and eye Acute percutaneous LD50 for rabbits >2000 mg/kg. Non-irritating to skin and slightly irritating to eyes (rabbits). Other Non-mutagenic in the Ames Test.

ENVIRONMENTAL FATE
Soil/Environment DT50 in soil 4 h (under irradiation), 8 h (in the dark). Low mobility in sandy loam soil.