Mesosulfuron-methyl 甲基二磺隆 甲磺胺磺隆

用于麦田除草。2013年10月14日到期。拜耳公司。2009年市场2.65亿美元。2002年上市。

新型除草剂甲磺胺磺隆

CAS号:208465-21-8

英文名称:Mesosulfuron-methyl

英文同义词:ATLANTIS;MESOMAXX;AEF154851;AEF130060;AEF6012-33H;MESOSULFURON;MESOSULFURON-METHYL;Mesosulfuron-methyl [iso];methyl 2-[3-(4,6-dimethyoxypyrimidin-2-yl)ureidosulfonyl]-4-methanesulfonamidomethybenzoate;Benzoic acid, 2-(4,6-dimethoxy-2-pyrimidinyl)aminocarbonylaminosulfonyl-4-(methylsulfonyl)amin

中文名称:甲磺胺磺隆

中文同义词:甲磺胺磺隆;2-[3-(4,6-二甲氧基嘧啶-2-基)脲磺酰]-4-甲磺酰胺甲基苯甲酸甲酯

CBNumber:CB4374509

分子式:C17H21N5O9S2

分子量:503.51

MOL File: 208465-21-8.mol

[作用特点] 磺酰脲类内吸传导型苗后选择性除草剂，是乙酰乳酸合酶 (ALS)的抑制剂。杂草叶片吸收药剂后即停止生长、逐渐枯死。该药在土壤中的残效期短，不影响下茬作物生长。

[制剂] 世玛３％油悬剂

[应用技术] 甲磺胺磺隆用于小麦田防除雀麦、节节麦、黑麦草、毒麦、网草、看麦娘、硬草、早熟禾、棒头草、碱茅、野燕麦等常见的禾本科杂草，对大部分阔叶杂草防效差。该药可与防除阔叶杂草的药剂混用，扩大杀草谱。适宜用药时期及用药量：小麦2－4叶期，杂草3叶期前，每亩用世玛３％油悬剂25－35毫升，加水25－30公斤喷雾。
该药施用时应尽量早用，杂草叶龄较大或天气干旱又无水浇条件时适当增加用药量。小麦拔节后不宜使用。

mesosulfuron-methyl
Herbicide
HRAC B WSSA 2; sulfonylurea

NOMENCLATURE
Common name mesosulfuron-methyl (BSI, pa ISO)
IUPAC name methyl 2-[(4,6-dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl]-a-(methanesulfonamido)-p-toluate
Chemical Abstracts name methyl 2-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]-4-[[(methylsulfonyl)amino]methyl]benzoate
CAS RN [208465-21-8] Development codes AE F130060; AE F154851 (acid) (both AgrEvo)

PHYSICAL CHEMISTRY
Mol. wt. 503.5 M.f. C17H21N5O9S2 Form Cream-coloured solid. M.p. 195.4 °C V.p. 1.1 ´ 10-8 mPa (25 °C) KOW logP = 1.39 (pH 5), -0.48 (pH 7), -2.06 (pH 9). Henry 2.434 ´ 10-10 Pa m3 mol-1 (pH 5, 20 °C) Solubility In water 7.24 ´ 10-3 (pH 5), 0.483 (pH 7), 15.39 (pH 9) (all in g/l, 20 °C). Stability Stable to photolysis. Abiotic hydrolysis DT50 3.5 (pH 4), 253 (pH 7), 319 (pH 9) (all in d, 25 °C).

COMMERCIALISATION
History Reported by E Hacker et al., (Proc. BCPC Conf. - Weeds, 2001, 1, 43), discovered in 1996, and under development by Aventis CropScience (now Bayer CropScience). Manufacturers Bayer CropScience

APPLICATIONS
Biochemistry Branched chain amino acid synthesis (ALS or AHAS) inhibitor. Acts by inhibiting biosynthesis of the essential amino acids valine and isoleucine, hence stopping cell division and plant growth. Mefenpyr-diethyl enhances metabolism of the herbicide selectively in cereal crop plants. Uses For early to mid post-emergence control of grass and some broad-leaved weeds in winter, spring and durum wheat, triticale and rye, at 15 g/ha. For use in combination with mefenpyr-diethyl at 45 g/ha. Selected products: mixtures: 'Mesomaxx' (+ mefenpyr-diethyl) (Bayer CropScience)

OTHER PRODUCTS
Mixtures: 'Archipel' (+ iodosulfuron-methyl-sodium+ mefenpyr-diethyl) (Bayer CropScience); 'Atlantis' (+ iodosulfuron-methyl-sodium+ mefenpyr-diethyl) (Bayer CropScience); 'Cossack' (+ iodosulfuron-methyl-sodium+ mefenpyr-diethyl) (Bayer CropScience)

MAMMALIAN TOXICOLOGY
Oral Acute oral LD50 for rats >5000 mg/kg. Skin and eye Acute dermal LD50 for rats >5000 mg/kg. Non-irritating to skin slightly irritant to eyes (rabbits). Not a skin sensitiser (guinea pigs). Inhalation LC50 >1.33 mg/l air. Other Not mutagenic.

ECOTOXICOLOGY
Birds Not toxic. Fish LC50 (96 h) 100 mg/l. Algae LC50 (96 h) 0.21 mg/l. Other aquatic spp. EC50 (7 d) for Lemna gibba 0.6mg/l. Bees Not toxic. Worms Not toxic.

ENVIRONMENTAL FATE
Soil/Environment Readily degraded, probably mainly by a microbial processes. Soil DT50 8-68 d (mean 39.1 d). Mesosulfuron-methyl and its metabolites are not transported in soil below 1 m, at or above the EU threshold for drinking water.