Mefenpyr-diethyl 吡唑解草酯


中文通用名称: 吡唑解草酯
英文通用名称: mefenpyr-diethyl (BSI,ISO)
试验代号: Hoe 107892、A E F107892
diethyl (RS)-1-(2,4-dichlorophenyl)-5-methyl-2-pyrazoline-3,5-dicarboxylate
diethyl 1-(2,4-dichlorophenyl)-4,5-dihydro-5-methyl-1H-pyrazole-3,5-dicarbox-ylate

化学结构类型: 吡唑类安全剂。
理化性质: 纯品为白色至粉色固体;熔点 50~52℃;密度1.31(20℃);分配系数LogP=3.83(25℃);水中溶解度为20mg/kg (pH 6.2, 20℃)。对酸碱稳定。

毒性: 大(小)鼠急性经口LD50:>5000mg/kg;大鼠急性经皮LD50:>4000mg/kg;大鼠急性吸入LC50:>1.32mg/l。鹌鹑急性经口LD50:>2000 mg/kg;鱼毒LC50 (96小时,mg/l):虹鳟4.2,鲤鱼2.4;

制剂: SC、SE、E W。
应用: 是恶唑禾草灵用于小麦、大麦等的安全剂。即同恶唑禾草灵一同使用可使作物小麦、大麦等免于伤害。

合成方法: 2,4-二氯苯肼与取代的烯酮二羧酸酯反应即得目的物。反应式为:

主要原料与中间体: 2,4-二氯苯肼
分析方法: GC HPLC
开发公司: 安万特公司。


Refer to <docbook-pesticides> for more data. Want more and better data of pesticides? Create your own ebook? Please visit:

Herbicide safener


Common name mefenpyr-diethyl (BSI, pa ISO)
IUPAC name diethyl (RS)-1-(2,4-dichlorophenyl)-5-methyl-2-pyrazoline-3,5-dicarboxylate
Chemical Abstracts name diethyl 1-(2,4-dichlorophenyl)-4,5-dihydro-5-methyl-1H-pyrazole-3,5-dicarboxylate
CAS RN [135590-91-9]; diacid [135591-00-3] Development codes Hoe 107892 (Hoechst); AE F107892 (AgrEvo)

Mol. wt. 373.2; (diacid 317.1) M.f. C16H18Cl2N2O4; (diacid C12H10Cl2N2O4) Form White to light beige crystals. M.p. 50-52 °C V.p. 6.3 ´ 10-3 mPa (20 °C); 1.4 ´ 10-2 mPa (25 °C) KOW logP = 3.83 (pH 6.3, 21 °C) Henry 2.55 ´ 10-4 Pa m3 mol-1 (20 °C) S.g./density c. 1.31 (20 °C) Solubility In water 20 mg/kg (pH 6.2, 20 °C). In acetone >500, toluene >400, ethyl acetate >400, methanol >400 (all in g/l, 20 °C). Stability Hydrolysed by acids and alkali.

Manufacturers Bayer CropScience

Biochemistry Enhances metabolism of mesosulfuron-methyl herbicide in cereal crop plants, but not in weeds. Uses Used as a herbicide safener in combination with fenoxaprop-P-ethyl, for selective weed control in wheat, rye, triticale and some barley varieties. Also under development for use in combination with iodosulfuron-methyl and with mesosulfuron-methyl. Phytotoxicity Not phytotoxic. Formulation types SC; SE; EW. Selected products: mixtures: 'Mesomaxx' (+ mesosulfuron-methyl) (Bayer CropScience); 'Puma Super' (+ fenoxaprop-P-ethyl) (Bayer CropScience)

Mixtures: 'Archipel' (+ mesosulfuron-methyl+ iodosulfuron-methyl-sodium) (Bayer CropScience); 'Atlantis' (+ mesosulfuron-methyl+ iodosulfuron-methyl-sodium) (Bayer CropScience); 'Baghera' (+ diclofop-methyl+ fenoxaprop-P-ethyl) (Bayer CropScience); 'Cheetah Super' (+ fenoxaprop-P-ethyl) (Bayer CropScience); 'Cossack' (+ mesosulfuron-methyl+ iodosulfuron-methyl-sodium) (Bayer CropScience); 'Djinn' (+ fenoxaprop-P-ethyl+ isoproturon) (Bayer CropScience); 'Dopler' (+ diclofop-methyl+ fenoxaprop-P-ethyl) (Bayer CropScience); 'Proper energy' (+ fenoxaprop-P-ethyl) (Bayer CropScience); 'Puma S' (+ fenoxaprop-P-ethyl) (Bayer CropScience); 'Zeus' (+ diclofop-methyl+ fenoxaprop-P-ethyl) (Bayer CropScience)

Oral Acute oral LD50 for rats and mice >5000 mg/kg. Skin and eye Acute percutaneous LD50 for rats >4000 mg/kg. Non-irritating to skin and eyes (rabbits); not a skin sensitiser (guinea pigs). Inhalation LC50 (4 h) for rats >1.32 mg/l. NOEL (2 y) for rats 48, mice 71 mg/kg b.w. daily. Other Non-mutagenic in vitro and in vivo.

Birds Acute oral LD50 for Japanese quail >2000 mg/kg. Fish LC50 (96 h) for carp 2.4, rainbow trout 4.2 mg/l. Daphnia LC50 (48 h) 53 mg/l. Algae EC50 for Navicula pelliculosa 1.65 mg/l. EbC50 (72 h) for Scenedesmus subspicatus 5.8 mg/l. Other aquatic spp. EC50 for Lemna gibba >12 mg/l. Bees LD50 (oral, 48 h) >900 mg/bee; (contact) >700 mg/bee. Worms LC50 (14 d) for Eisenia foetida >1000 mg/kg soil.

Soil/Environment Abiotic hydrolysis DT50 >365 d (pH 5), 40.9 d (pH 7), 0.35 d (pH 9) (25 °C). Photodegradation DT50 2.9 d. Completely mineralised in soil by hydrolysis, microbial and photolytic degradation processes; DT50 <10 d. Not leached (no single residual compound in leachates at concentration >0.1 mg/l).