Lufenuron 虱螨脲，八氟脲

虱螨脲

简介
ISO 通用名称 : Lufenuron 虱螨脲
化学名称 .: RS）-1-[2，5-二氯-4-（1，1，2，3，3，3-六氟丙氧基）苯基]-3-（2，6-二氟苯甲酰基）脲
CAS 登记号 : 103055-07-8
分子式 : C17H8Cl2F8N2O3
含量：97%
常用剂型：5%EC

理化性质
外观： 白色结晶体。
熔 虱螨脲
点 164.7-167.7°C ；
蒸汽压<1.2 X 10 -9 Pa （ 25 °C ）；
水中溶解度（ 20°C ）<0.006mg/L 。
其它溶剂 溶解度（ 20°C ， g/L ）：甲醇 41 、丙酮 460 、甲苯 72 、正己烷 0.13 、正辛醇 8.9 。稳定性：在空气、光照下稳定，在水中 DT 50 ： 32 天（ pH9 ）、 70 天（ pH7 ）、 160 天（ pH5 ）。

产品用途
主要用于防治棉花、玉米、蔬菜、果树等鳞翅目等幼虫；也可作为卫生用药；还可用于防治动物如牛等的害虫。

农业推广
的最新一代取代脲类杀虫剂。药剂通过作用于昆虫幼虫、阻止脱皮过程而杀死害虫，尤其对果树等食叶毛虫有出色的防效，对蓟马、锈螨、白粉虱有独特的杀灭机理，适于防治对合成除虫菊酯和有机磷农药产生抗性害虫。药剂的持效期长，有利于减少打药次数；对作物安全，玉米、蔬菜、柑橘、棉花、马铃薯、葡萄、大豆等作物均可使用，适合于综合虫害治理。药剂不会引起刺吸式口器害虫再猖獗，对益虫的成虫和扑食性蜘蛛作用温和。药效持久，耐雨水冲刷，对有益的节肢动物成虫具有选择性。用药后，首次作用缓慢，有杀卵功能，可杀灭新产虫卵，施药后2~3天见效果。对蜜蜂和大黄蜂低毒，对哺乳动物虱螨低毒，蜜蜂采蜜时可以使用。比有机磷、氨基甲酸酯类农药相对更安全，可作为良好的混配剂使用，对鳞翅目害虫有良好的防效。低计量使用，仍然对毛虫有良好防效，对花蓟马幼虫有良好防效；可阻止病毒传播，可有效控制对菊酯类和有机磷有抗性的鳞翅目害虫。药剂有选择性，长持性，对后期土豆蛀茎虫有良好的防治效果。美除减少喷施次数，能显著增产。 使用方法：对于卷叶虫、潜夜蝇、苹果锈螨、苹果蠹蛾等，可用有效成分5克对水100公斤进行喷雾。对于番茄夜蛾、甜菜夜蛾、花蓟马、西红柿、棉铃虫、土豆蛀茎虫、西红柿锈螨、茄子蛀果虫、小菜蛾等，可用3~4克有效成分对水100公斤进行喷雾。使用时，要注意与库龙、害极灭、伊维菌素等其他农药交替用药。

lufenuron
Insecticide, acaricide
IRAC 15; benzoylurea

NOMENCLATURE
Common name lufenuron (BSI, pa E-ISO, INN)
IUPAC name (RS)-1-[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-3-(2,6-difluorobenzoyl)urea
Chemical Abstracts name N-[[[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]amino]carbonyl]-2,6-difluorobenzamide
CAS RN [103055-07-8] Development codes CGA 184699 (Ciba-Geigy)

PHYSICAL CHEMISTRY
Composition Tech. is ³98%. Mol. wt. 511.2 M.f. C17H8Cl2F8N2O3 Form Colourless crystals. M.p. 168.7-169.4 °C (OECD 102) V.p. <4 ´ 10-3 mPa (25 ºC) (OECD 104) KOW logP = 5.12 (25 ºC) (OECD 117) Henry <3.41 ´ 10-2 Pa m3 mol-1 (calc.) S.g./density 1.66 at 20 ºC (OECD 109) Solubility In water <0.06 mg/l (25 ºC). In ethanol 41, acetone 460, toluene 72, n-hexane 0.13, n-octanol 8.9 (all in g/l, 25 ºC). Stability Stable in air and light. In water, DT50 32 d (pH 9), 70 d (pH 7), 160 d (pH 5). pKa >8.0

COMMERCIALISATION
History Reported in poster session at RSC/SCI conference "Chemistry of Insecticides", Oxford, July 1989. Introduced by Ciba-Geigy (now Syngenta AG) in 1990. Manufacturers Syngenta

APPLICATIONS
Biochemistry Inhibits chitin synthesis. Mode of action Acts mostly by ingestion; larvae are unable to moult, and also cease feeding. Uses Insect growth regulator for control of Lepidoptera and Coleoptera larvae on cotton, maize and vegetables; and citrus whitefly and rust mites on citrus fruit, at 10-50 g/ha. Also for the prevention and control of flea infestations on pets. Formulation types EC. Compatibility Not compatible with pesticides with alkaline reaction (lime sulfur, copper). Selected products: 'Match' (Syngenta)

OTHER PRODUCTS
'Axor' (Syngenta); 'Program' (Syngenta) mixtures: 'Lufox' (+ fenoxycarb) (Syngenta) Discontinued products: 'Instar' * (Ciba-Geigy)

ANALYSIS
Residue analysis by hplc. Details available from Syngenta.

MAMMALIAN TOXICOLOGY
Oral Acute oral LD50 for rats >2000 mg/kg. Skin and eye Acute percutaneous LD50 for rats >2000 mg/kg. Non-irritating to eyes and skin (rabbits). Non-sensitising to skin (guinea pigs). Inhalation LC50 (4 h, 20 ºC) for rats >2.35 mg/l air. NOEL (2 y) for rats 2.0 mg/kg b.w. daily. ADI 0.01 mg/kg. Toxicity class WHO (a.i.) III (company classification) EC classification R43| N; R50, R53

ECOTOXICOLOGY
Birds Acute oral LD50 for bobwhite quail and mallard ducks >2000 mg/kg. Dietary LC50 (8 d) for bobwhite quail and mallard ducks >5200 mg/kg. Fish LC50 (96 h) for rainbow trout >73, carp >63, bluegill sunfish >29, catfish >45 mg/l. Daphnia Toxic to Daphnia. Algae Slightly toxic to algae. Bees LC50 (oral) >197 mg/bee. LD50 (topical) >200 mg/bee. Worms No adverse effects on earthworms.

ENVIRONMENTAL FATE
Animals Major route of elimination was via faeces, with very little degradation. Plants No metabolites occurred in significant amounts in the investigated target crops (cotton, tomatoes). Soil/Environment Lufenuron was rapidly degraded in biologically active soils under aerobic conditions. DT50 13-20 d. Lufenuron showed a very strong adsorption onto soil particles: Koc (mean value) 38 mg/g o.c.