Imazethapyr 咪草烟

请下载《资料收集库-农药电子书》获得更多农药资料。想获得更多更系统的农药资料?想创建自己的农资电子书?请访问 http://www.9ele.com/pesticide.html


咪草烟

产品名称: 咪草烟原药
产品类别: 原药
通用名:咪唑乙烟酸、咪草烟、普杀特、普施特
CAS NO: [81335-77-5]
化学名称:(RS)5-乙基-2-(4-异丙基-4-甲基-5-氧代-3-咪唑啉-2-基)烟酸
化学文摘名称: 2-[4,5-二氢-4-甲基-4-(1-甲基乙基)-5-羰基-1H-咪唑-2-基]-5-乙基-3-吡啶羧酸
分子式:C15H19N3O3
分子量:289.3
中科院登记号:81335-77-5

理化性质
熔 点:169℃-173℃
蒸气压:0.013mpa(60℃)
溶解度(g/L,25℃): 水1.4;丙酮48.2;三氯甲烷185;甲苯5;异丙醇17;甲醇105
Kow logP = 1.04 (pH 5), 1.49 (pH 7), 1.20 (pH 9) (all 25 ºC)
稳定性:在酸性及中性条件下稳定,遇强碱分解。
产品特点:
原药质量指标
项目 标准值
外观 淡黄色至白色结晶固体,无可见外来杂质
含量 ≥98.0%
PH 3.0-5.0
加热减量 ≤1.0%
固体不溶物 ≤1.0%
用途:用于豆科作物防除禾本科杂草及阔叶杂草.

用途
咪唑啉酮类除草剂,是侧链氨基酸合成抑制剂,芽前或芽后施用。对大豆田和其他豆科植物田的禾本科杂草和某些阔叶杂草有优异的防效,如苋菜、蓼、藜、龙葵、苍耳、稗草、狗尾草、马唐、黍等。可制成水剂。 施药方法:苗期(大豆真叶期至2片复叶期、杂草1~4叶期),每公顷1000~2000ml5%水剂,对水450~600kg均匀喷雾。插后苗期(土壤墒情好时),每公顷1500~2250ml5%水剂,对水450~600kg均匀喷雾。 注意事项:施药均匀、周到,避免重复施药,一年内仅可施药一次;避免飞机高空施药;施药时切不可漂移至敏感作物上;敏感作物有甜菜、白菜、油菜、西瓜、黄瓜、马铃薯、茄子、辣椒、番茄、高粱等,上述作物在第二年内不能种植,甜菜三年内不能种植;本制剂适于东北大豆产区,未应用过的地区应在农技部门指导下试验后推广。

制备或来源
双乙烯酮在二氯甲烷中用氯气处理,得氯代乙酰乙酸乙酯,该化合物与二氯砜在三氯甲烷中,于室温下反应10小时,得2,4-二氯代乙酰乙酸乙酯,再与2-乙基丙烯醛和氨基磺酸铵在无水乙醇中回流1.5小时,制得2-氯甲基-5-乙基烟酸乙酯,后者与2-氨基-2,3-二甲基丁酰胺和碳酸氢钠在二甲基亚砜中,于80℃下反应16小时,得到的缩合物再水解,然后在乙酸中环合即得咪草烟。
备注:勿在未衬里的不锈钢或铝容器中贮存或混合,有腐蚀性;不能与强氧化剂混合。避免药物接触皮肤、眼睛或玷污衣物;避免吸入液雾。药剂一旦接触皮肤、眼睛应用大量清水冲洗;不慎误服时,勿催吐应立即送医院诊治。

生态毒理学
鸟类:急性经口LD50,鹌鹑和绿头鸭2150年毫克/千克。
鱼类:半致死浓度( 96小时)为420毫克/升翻车鱼,虹鳟鱼毫克/升340个,鲶鱼240毫克/升
蚤:半致死浓度( 48小时) 1000毫克/升
海藻:月牙藻50毫克/升,其他水生草浮萍为4.38毫克/升
蜜蜂:局部蜜蜂的LD50为0.1毫克/升。
虫类: I50~10 000毫克/升。
环境转移
动物:在大鼠后,口服,92 %是排出的尿液和5 %的粪便,24小时内,血液,肝脏,肾脏,肌肉,脂肪组织的残留水平较多。
植物:快速新陈代谢的非敏感植物;半衰期大豆一点六天,主要代谢途径是在玉米氧化羟化在一个碳原子的乙基取代的吡啶环。
土壤/环境:半衰期在土壤中1-3个月。

包装及贮运
本品在贮存、运输和施药过程中切勿污染食物和饲料。

 

Refer to <docbook-pesticides> for more data. Want more and better data of pesticides? Create your own ebook? Please visit: http://www.9ele.com/pesticide_en.html


imazethapyr
Herbicide
HRAC B WSSA 2; imidazolinone

  imazethapyr

NOMENCLATURE
imazethapyr
Common name imazethapyr (BSI, ANSI, draft E-ISO, (m) draft F-ISO)
IUPAC name (RS)-5-ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid
Chemical Abstracts name (?-2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-yl]-5-ethyl-3-pyridinecarboxylic acid
CAS RN [81335-77-5] Development codes AC 263 499; CL 263 499 (both Cyanamid)

imazethapyr-ammonium
CAS RN [101917-66-2]

PHYSICAL CHEMISTRY
imazethapyr
Mol. wt. 289.3 M.f. C15H19N3O3 Form Off-white to tan solid. M.p. 169-173 ºC B.p. Decomp. 180 °C V.p. <0.013 mPa (60 ºC) KOW logP = 1.04 (pH 5), 1.49 (pH 7), 1.20 (pH 9) (all 25 ºC) Henry 2.69 ´ 10-6 Pa m3 mol-1 S.g./density 1.10-1.12 (21 °C) Solubility In water 1.4 g/l (25 ºC). In acetone 48.2, methanol 105, toluene 5, dichloromethane 185, dimethyl sulfoxide 422, isopropanol 17, heptane 0.9 (all in g/l, 25 ºC). Stability Rapidly degraded in sunlight, DT50 c. 2.1 d (pH 7, 22-24 °C). pKa pKa1 2.1, pKa2 3.9

imazethapyr-ammonium
Mol. wt. 306.4 M.f. C15H22N4O3

COMMERCIALISATION
History Herbicide reported by T. Malefyt et al. (Abstr. 1984 Weed Sci. Soc. Mtg., Miami, p. 18, Abstract 49). Introduced by American Cyanamid Co. (now BASF AG) in 1989 with first registration for soya beans. Patents US 4798619 Manufacturers BASF; Milenia; Sannong; Sharda; Shenyang

APPLICATIONS
Biochemistry Branched chain amino acid synthesis (ALS or AHAS) inhibitor. Hence reduces levels of valine, leucine and isoleucine, leading to disruption of protein and DNA synthesis. Selectivity in soya benas and peanuts is attributed to rapid detoxification via hydroxylation and glycosylation (B. Tecle et al., Proc. 1997 Br. Crop Prot. Conf. - Weeds, 2,605). Mode of action Systemic herbicide, absorbed by the roots and foliage, with translocation in the xylem and phloem, and accumulation in the meristematic regions. Uses Control of many major annual and perennial grass and broad-leaved weeds in most major crops, at 2-4 oz/a. Applied pre-plant incorporated, pre-emergence, or post-emergence. Phytotoxicity Non-phytotoxic to soya beans and other leguminous crops, when used as directed. Formulation types Aqueous solution; WG. Compatibility Full rate application of products containing chlorimuron-ethyl, cloransulam-methyl, flumetsulam or other imazethapyr products applied the same year as 'Pursuit' may increase the risk of injury to sensitive follow-crops.

imazethapyr
Selected products: 'Newpath' (BASF); 'Vezir' (Makhteshim-Agan, Milenia)

imazethapyr-ammonium
Selected products: 'Hammer' (BASF); 'Overtop' (BASF, DuPont); 'Pivot' (BASF); 'Pursuit' (BASF)

OTHER PRODUCTS
imazethapyr
'Vrilec' (IPESA) mixtures: 'Absolute' (+ clopyralid+ imazamox) (potassium salts) (BASF); 'Alteza' (+ glyphosate) (BASF); 'Elite' (+ pendimethalin) (BASF); 'Extreme' (+ glyphosate-isopropylammonium) (BASF); 'Lightning' (+ imazapyr) (BASF); 'Odyssey' (+ imazamox) (Canada) (BASF); 'Pursuit Plus' (+ pendimethalin) (BASF); 'Standout' (+ glyphosate) (BASF); 'Steel' (+ pendimethalin+ imazaquin) (BASF); 'Flier' (+ glyphosate) (IPESA) Discontinued products: 'Event' * (Cyanamid); 'ImPede' * (Cyanamid); 'Wayup' * (BASF) mixtures: 'Clean Sweep' * (+ bentazone) (BASF); 'Passport' * (+ trifluralin) (BASF); 'Resolve' * (+ dicamba-sodium) (BASF); 'Structure' * (+ pendimethalin+ imazaquin) (BASF)

imazethapyr-ammonium
Discontinued products mixtures: 'Contour' * (+ atrazine) (BASF)

MAMMALIAN TOXICOLOGY
Oral Acute oral LD50 for male and female rats, and female mice >5000 mg/kg. Skin and eye Acute percutaneous LD50 for rabbits >2000 mg/kg; not a skin irritant, and reversible eye irritant. Inhalation LC50 for rats 3.27 mg/l air (analytical), 4.21 mg/l (gravimetric). NOEL (2 y) for rats >500 mg/kg b.w. daily; (1 y) for dogs >25 mg/kg b.w. daily. ADI 0.25 mg/kg b.w. Other Non-mutagenic in the Ames test. Toxicity class WHO (a.i.) U; EPA (formulation) III

ECOTOXICOLOGY
imazethapyr
Birds Acute oral LD50 for bobwhite quail and mallard ducks >2150 mg/kg. LC50 (8 d) for bobwhite quail and mallard ducks >5000 mg/kg. Fish LC50 (96 h) for bluegill sunfish 420, rainbow trout 340, channel catfish 240 mg/l. Daphnia LC50 (48 h) >1000 mg/l. Algae NOEL for Selenastrum capricornutum 50 mg/l. Other aquatic spp. EC50 (14 d) for Lemna gibba 10.1 mg/l Bees LD50 (oral, 48 h) >24.6 µg/bee; contact (48 h) >100 µg/bee. Worms LC50 (14 d) >15.7 mg/kg soil.

ENVIRONMENTAL FATE
Animals In rats, following oral administration, 95% was excreted in urine and faeces within 48 hrs. Residue levels in blood, liver, kidney, muscle, and fat tissues were <0.01 ppm after 48 hours. Plants Rapidly metabolised in non-susceptible plants, soya beans, maize, alfalfa. The primary metabolic route in all crops tested is oxidative hydroxylation at the a-carbon atom of the ethyl substituent on the pyridine ring. Soil/Environment DT50 lab. (aerobic, 20 °C) 158 d. Photolytic degradation DT50 (pH7, 22-24 °C) 2.1 d.