Hexythiazox 噻螨酮

噻螨酮

通用名称 hexythiazox
别 名尼索朗噻螨酮结构式
化学名称 5-(4-氯苯基)-3-(N-环己基氨基甲酰)-4-甲朗基噻唑烷-2-酮
CAS登记号 [ 78587- 05-0 ]
分子式 C17H21ClN2O2S
结构式见右图
分子量 352.9
理化性质 原药为浅黄色或白色结晶，熔点108～108.5°C，20°C时蒸气压为338.6×10-8Pa，水中溶解度为0.5毫克/升，在每100毫克的甲醇、己烷、丙酮等有机溶剂中的溶解度分别为 2.06克、0.39克、16.0克，50°C下保存3个月不分解。
毒性 大鼠急性经口 LD50>5000mg/kg，大鼠急性经皮LD50>5000mg/kg，低毒。

用途
对多种植物害螨具有强烈的杀卵、杀幼若螨的特性，对成螨无效，但对接触到药液的雌成虫所产的卵具有抑制孵化的作用。对叶螨防效好，对锈螨、瘿螨防效较差。可与波尔多液、石硫合剂等多种农药混用。 以触杀作用为主，对植物组织有良好的渗透性，无内吸性作用。防治苹果红蜘蛛，在幼若螨盛发期，平均每叶有3～4只螨时，用5%乳油或5%可湿性粉剂1500～2000倍液喷雾。收获前7d停止使用。

药剂特性
本品为噻唑烷酮类杀螨剂，有效成分为噻螨酮。乳油外观为淡黄色或浅棕色液体，可湿性粉剂外观为灰白色粉末，在阴凉干燥条件下保存2年不变质。对人、畜低毒，对眼有轻微刺激作用，对鸟类低毒，在常量下对蜜蜂无毒性反应，对天敌影响很小，对鱼类有毒。对害螨具有杀卵、杀若螨作用，但对成螨无杀伤作用。环境温度高低不影响使用效果，一般施药后10天才能显示出较好的防效，持效期可保持50天左右。

注意事项
（1）在蔬菜收获前30天停用。在1年内，只使用1次为宜；
（2）本剂可与波尔多液、石硫合剂等多种农药混用，但波尔多液的浓度不能过高；
（3）本剂宜在成螨数量较少时（初发生时）使用，若是螨害发生严重时，不宜单独使用本剂，最好与其他具有杀成螨作用的药剂混用。

其他信息
[规格] 原药含量 ≥99%
[包装] 25kg/纸板桶，也可按客户要求包装。
[制剂] 5%EC,10%WP
[适用作物] 柑橘、苹果、棉花、山楂。

hexythiazox
Acaricide
IRAC 10A; mite growth inhibitor

NOMENCLATURE
Common name hexythiazox (BSI, draft E-ISO, (m) draft F-ISO)
IUPAC name (4RS,5RS)-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-1,3-thiazolidine-3-carboxamide
Chemical Abstracts name trans-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxamide
CAS RN [78587-05-0] Development codes NA-73 (Nippon Soda)

PHYSICAL CHEMISTRY
Mol. wt. 352.9 M.f. C17H21ClN2O2S Form Colourless crystals. M.p. 108.0-108.5 ºC V.p. 0.0034 mPa (20 ºC) KOW logP = 2.53 Henry 2.40 ´ 10-3 Pa m3 mol-1 (calc.) Solubility In water 0.5 mg/l (20 ºC). In chloroform 1379, xylene 362, methanol 206, acetone 160, acetonitrile 28.6, hexane 4 (all in g/l, 20 ºC). Stability Stable to light, air and heat, and in acidic and alkaline media. Stable to 300 ºC. Aqueous solution in sunlight DT50 16.7 d.

COMMERCIALISATION
History Acaricide reported by T. Yamada (Proc. Int. Congr. Pestic. Chem., Kyoto, 5th, 1982), see also Jpn. Pestic. Inf., 1984, No. 44, p. 21. Introduced by Nippon Soda Co., Ltd. Registered in Japan in 1985. Patents GB 2059961; US 4442116 Manufacturers Nippon Soda

APPLICATIONS
Mode of action Non-systemic acaricide with contact and stomach action. Good translaminar activity. Has ovicidal, larvicidal, and nymphicidal activity. Not active against adults, but eggs laid by treated females are non-viable. Uses Control of eggs and larvae of many phytophagous mites (particularly Panonychus, Tetranychus, and Eotetranychus spp.) on fruit, citrus, vegetables (all at 150-300 g/ha), vines and cotton. Formulation types EC; FU; WP. Selected products: 'Nissorun' (Nippon Soda); 'Savey' (Nippon Soda); 'Cesar' (Bayer CropScience); 'Hexygon' (Gowan); 'Matacar' (Sipcam); 'Ordoval' (BASF); 'Vittoria' (Rocca); 'Zeldox' (Syngenta Spain)

OTHER PRODUCTS
'Acarflor' (Sipcam); 'Calibre' (BASF); 'Onager' (Gowan); 'Stopper' (Bayer CropScience)

ANALYSIS
Product and residue analysis by hplc (M. Tokieda et al., J. Pestic. Sci., 1987, 12, 711).

MAMMALIAN TOXICOLOGY
Reviews FAO/WHO 62, 64 (see part 2 of the Bibliography). Oral Acute oral LD50 for rats and mice >5000 mg/kg. Skin and eye Acute percutaneous LD50 for rats >5000 mg/kg. Mild eye irritant; non-irritating to skin (rabbits). Non-sensitising to skin (guinea pigs). Inhalation LC50 (4 h) for rats >2 mg/l air. NOEL (2 y) for rats 23.1 mg/kg b.w.; (1 y) for dogs 2.87 mg/kg b.w.; (90 d) for rats 70 mg/kg diet. ADI (JMPR) 0.03 mg/kg [1991]. Other Non-teratogenic. Not mutagenic in the Ames assay. Toxicity class WHO (a.i.) U; EPA (formulation) IV EC classification N; R50, R53

ECOTOXICOLOGY
Birds Acute oral LD50 for mallard ducks >2510, Japanese quail >5000 mg/kg. Dietary LC50 (8 d) for mallard ducks and bobwhite quail >5620 mg/kg diet. Fish LC50 (96 h) for rainbow trout >300, bluegill sunfish 11.6 mg/l; (48 h) for carp 3.7 mg/l. Daphnia LC50 (48 h) 1.2 mg/l. Bees Not toxic to bees. LD50 by topical application >200 mg/bee.

ENVIRONMENTAL FATE
Animals The main metabolite in urine and faeces is 5-(4-chlorophenyl)-N-(cis-4-hydroxycyclohexyl)-4-methyl-trans-2-oxothiazolidine-3-carboxamide. Soil/Environment DT50 in clay loam at 15 ºC, 8 d. In soil, undergoes oxidation to the corresponding hydroxy and carbonyl compounds. Koc 6200.