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Fufenozide
JS-118 is an extensively used insecticide in China. The present study investigated the genotoxic effect of JS-118 on whole blood at 24, 48, 72 and 96 h by using alkaline comet assay. Male Kunming mice were given 6.25, 12.5, 25, 50 and 100 mg/kg BW of JS-118 intraperitoneally. A statistically significant increase in all comet parameters indicating DNA damage was observed at 24 h post-treatment (p < 0.05). A clear concentration-dependent increase of DNA damage was revealed as evident by the OTM (arbitrary units), tail length (µm) and tail DNA (%). From 48 h post-treatment, a gradual decrease in mean comet parameters was noted. By 96 h of post-treatment, the mean comet tail length reached control levels indicating repair of damaged DNA. This study on mice showed different DNA damage depending on the concentration of JS-118 and the period of treatment. The present study provided further information of the potential risk of the genetic damage caused by JS-118.
Mode: insect growth regulator
Source: Organic Synthesis
Appearance: off-white powder
Development codes：JS118
Chemical Abstracts name： 6-benzofurancarboxylic acid, 2,3-dihydro-2,7-dimethyl-2-(3,5-dimethybenzoyl)-2-(1,1-dimethylethyl)-hydrazide
Biochemistry： Ecdysone agonist which acts by binding to the receptor site of the insect moulting hormone, ecdysone.
Mode of action：Lethally accelerates moulting process.
Formulation types: SC, WP
Fufenozide is a novel insecticide with Intellectual Property, safe to natural enemy of insect, for example, acarid, bees, pulse wing item, and beetle. Lower toxicity to mammalian such as people, domestic animal, aves, fish and bees. Fufenozide is provide with high efficiency to all lepidopterous pests which is dangerous to agricultural production at present and it also can be used on crops and forest to prevention lepidopterous pests, cotton, nut, apple, sugar cane, orange, rice, vegetable and sugar beet and so on. Proved by test, it is uneasy for pest to bring fastness after using Fufenozide ,especially on plutella xylostella. This character not only ensures the efficiency, but also solute the problem which efficiency decreases after pesticide fastness appears.
The mechanism of fufenozide is imitate ecdysone, which is an insect growth regulator with resemble living property.Attack insect growth and development system, restrain ecdysis and new cuticle form to prevention and cure pest.
Fufenozide can be used to prevention all kinds of lepidopterous pests in agricultural production, vegetable fruit, and economic crops, such as beet armyworm, Spodoptera litura, plutella xylostella, tea geometrid and all kinds of borers.Fufenozide is a high efficiency and lower poison green chemical pesticide and it only need 75g/ha.There is no similar product both in domestic and abroad.
Fufenozide is provide with high efficiency to all lepidopterous pests which is dangerous to agricultural production at present and it also can be used on crops and forest to prevention lepidopterous pests, cotton, nut, apple, sugar cane, orange, rice, vegetable and sugar beet and so on.
Insect Crop LC50/LD50
(mg/L , ug/pest)
Spodoptera exigua
Beet armyworm Vegetable, maize 3.055
Plutella xylostella
Diamond back moth Vegetable 69.04
Ectropis oblique
Tea geometrid Tea tree 26.01
Cnaphalocrocis medinalis
rice leaf roller rice
Chilo suppressalis
Rice striped borer rice 0.0216 ug/pest
Leucania separate
Oriental armyworm wheat < 3
Ostrinia furnacalis
Asiatic corn borer maize 48.69
Artogeia rapae
cabbage butterfly Vegetables 100% / 20ppm
Spodoptera exigua Savoy Cabbage 100% / 20ppm
Plutella xylostella Savoy Cabbage 100% / 20ppm
Heliothis armigera Soya 100% / 20ppm
Spodoptera frugiperda Savoy Cabbage 100% / 20ppm
Prodenia litura
tobacco caterpillar Vegetables, lawn 48.3% / 100ppm
Phyllocnistis citrella
citrus leaf-miner citrus 80% / 200ppm
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