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Fluxapyroxad
Common Name: Fluxapyroxad
Name:
IUPAC Name: 3-(difluoromethyl)-1-methyl-N-(3′,4′,5′-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide
CAS Name: 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluoro[1,1'-biphenyl]-2-yl)-1H-pyrazole-4-carboxamide
CAS No.:907204-31-3
Formula: C18H12F5N3O
Molecular weight：381.30
Chemical Structure:
Year of Initial Registration 2012 in USA
Pesticide Type: Fungicide
Chemical Class: Carboxamide
Company: BASF Corporation
Mode of Action: Inhibition of succinate dehydrogenase in complex II of the mitochondrial respiratory chain
USE PATTERN AND FORMULATIONS:
Fluxapyroxad is a new active ingredient (a.i.) developed by BASF Corporation to control a broad spectrum of fungal diseases. Fluxapyroxad belongs to the carboxamide class of chemicals and its mode of action is inhibition of succinate dehydrogenase in complex II of the mitochondrial respiratory chain, which results in inhibition of spore germination, germ tubes, and mycelial growth within the fungus target species.
Fluxapyroxad is formulated as an emulsifiable concentrate (EC) or suspension concentrate (SC) and is registered for both foliar and seed treatment uses on a wide range of crops (cereal grains, legume vegetables, oil seed crops, peanuts, pome fruit, stone fruit, root and tuber vegetables, fruiting vegetables, and cotton). Crop applications may begin at emergence, but typical applications begin as plants touch across rows. Maximum single application rates range from 0.09 to 0.18 lb ai/acre. Maximum seasonal application rates range from 0.18 to 0.36 lb ai/acre. Pre-harvest intervals (PHIs) range from 0 to 21 days. A 365-day plant-back interval (PBI) is required for all crops that are not on the label. Applications may be made using groundboom, airblast, aerial, and standard slurry or mist-type seed treatment equipment. There are no fluxapyroxad products for homeowner use and there are no products for application to residential areas.
Physical and chemical properties:
Melting point/range: 156.8 °C
pH of 1% solution in water: 5.8
Density: 1.47
Water solubility ( 20°C): 3.88 mg/L at pH 5.8 (not buffered); 3.78 mg/L at pH 4; 3.44 mg/L at pH 7 3.84 mg/L at pH 9
Solvent solubility (g/L at 20°C): acetone >250; acetonitrile 167.6 ± 0.2; dichloromethane 146.1 ± 0.3; ethylacetate 123.3 ± 0.2; methanol 53.4 ± 0.0; toluene 20.0 ± 0.0; n-octanol 4.69 ± 0.01; n-heptane 0.106 ± 0.001
Vapor pressure at 25 °C: 8.1 x 10-9 Pa
Dissociation constant (pKa): 12. 58 (calculated)
Octanol/water partition coefficient Log(KOW): 3.08 (deionized water) 3.09 at pH 4 3.13 at pH 7 3.09 at pH 9
Acute Toxicity
Study Type Results Toxicity Category
Acute oral – rat (females) LD50 = >2000 mg/kg III
Acute dermal – rat LD50 >2000 mg/kgM & F III
Acute inhalation – rat LC50 >5.1 mg/L M & F IV
Acute eye irritation – rabbit Slightly irritating IV
Acute dermal irritation – rabbit Slightly irritating IV
Dermal sensitization – guinea pig No sensitization -
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