Flumetralin 氟节胺

氟节胺

性质

flumetralin
黄色结晶。熔点101～103℃。20℃水中的溶解度为0.1mg/L。易溶于苯、二氯甲烷。
大鼠急性经口LD505000mg/kg，急性经皮LD502000mg/kg对皮肤刺激中等，对眼睛刺激强烈。
制剂有20％和15％乳剂。
植物生长调节剂。
由2,6-二硝基-4-三氟甲基氯苯与N-乙基-N-(2-氯-6-氟苄基)胺反应生成。
局部用本品处理可控制烟草侧芽，并在整个生长季节有效。

对比

12％氟节胺EC(配方A、B、C、D)、12．5％抑芽敏EC及25％灭芽灵EC的田间试验结果表明，药后三周各药剂对烟草的芽鲜重抑制率均在95％以上，效果均娃，其中以12％氟节胺EC配方D最佳。在制剂质量方面，12％氟节胺EC的各个配方均要显著优于25％灭芽灵EC，配方A、配方B、配方D优于12．5％抑芽敏EC，配方D最佳。湿展能力的不同是造成各药剂药效与制剂质量不同的关键因素。利用帆布沉降法测得12％氟节胺EC各配方及12．5％抑芽敏EC的润湿时间小于2min，25％灭芽灵EC大于2h

中毒急救
中毒症状

对眼、口、鼻及皮肤有刺激作用。一般无全身毒性。

急救治疗：
无特效解毒剂，需对症治疗。如误服本剂，应给患者服用大量医用活性炭，但不要给昏迷患者喂食任何东西。

注意事项

[1]本品对2.5cm以上的侧芽效果不好施药时应事先打去。
[2]本品对鱼有毒，应避免药剂污染水塘、河流。
[3]不能与其它农药混用。

flumetralin
Plant growth regulator

 NOMENCLATURE
Common name flumetralin (BSI, draft E-ISO); flumétraline ((f) draft F-ISO)
IUPAC name N-(2-chloro-6-fluorobenzyl)-N-ethyl-a,a,a-trifluoro-2,6-dinitro-p-toluidine
Chemical Abstracts name 2-chloro-N-[2,6-dinitro-4-(trifluoromethyl)phenyl]-N-ethyl-6-fluorobenzenemethanamine
CAS RN [62924-70-3] Development codes CGA 41 065 (Ciba-Geigy)

PHYSICAL CHEMISTRY
Mol. wt. 421.7 M.f. C16H12ClF4N3O4 Form Yellow to orange, odourless crystals. M.p. 101.0-103.0 ºC; (tech., 92.4-103.8 ºC) V.p. 3.2 ´ 10-2 mPa (25 ºC) (OECD 104) KOW logP = 5.45 (25 ºC) Henry 0.19 Pa m3 mol-1 (calc.) S.g./density 1.54 Solubility In water 0.07 mg/l (25 ºC). In acetone 560, toluene 400, ethanol 18, n-hexane 14, n-octanol 6.8 (all in g/l, 25 ºC). Stability Decomposes exothermically above 250 ºC. Hydrolytically stable between pH 5 and pH 9.

COMMERCIALISATION
History Plant growth regulator reported by M. Wilcox et al. (Proc. Plant Growth Regul. Working Group, 1977, 4, 194). Introduced by Ciba-Geigy AG (now Syngenta AG) and first marketed in 1983. Patents BE 891327; GB 1531260 Manufacturers Milenia; Syngenta; Zhejiang

APPLICATIONS
Mode of action Plant growth regulator, which has a local systemic effect. Uses Control of sucker growth in tobacco, applied at 10-15 ml of 1-35% solution per plant. Phytotoxicity May cause some injury to immature plants. Formulation types EC. Selected products: 'Prime' (Syngenta); 'Prime+' (Syngenta)

OTHER PRODUCTS
'Podos' (Milenia); 'Yiyaming' (Zhejiang) Discontinued products: 'Premier' * (Ciba)

ANALYSIS
Residues determined by glc using ECD or FID. Details available from Syngenta.

MAMMALIAN TOXICOLOGY
Oral Acute oral LD50 for rats >5000 mg/kg. Skin and eye Acute percutaneous LD50 for rats >2000 mg/kg. EC formulation (150 g/l) is a moderate skin irritant and an extreme eye irritant. Inhalation LC50 for rats >2130 mg/m3. NOEL (2 y) for rats and mice 300 ppm. ADI 0.17 mg/kg. Toxicity class WHO (a.i.) U EC classification Xi; R36/38| R43| N; R50, R53

ECOTOXICOLOGY
Birds LD50 for bobwhite quail and mallard ducklings >2000 mg/kg. LC50 for mallard ducklings and bobwhite quail >5000 ppm. Fish Toxic to fish; LC50 for bluegill sunfish 18, trout 25 mg/l. Daphnia LC50 (48 h) >66 mg/l. Algae EC50 for Selenastrum >0.85 mg/l. Other aquatic spp. EdC50 for Lemna gibba 0.15 mg/l. Bees Non-toxic. Worms LC50 for earthworms >1000 mg/kg.

ENVIRONMENTAL FATE
Animals Metabolic reactions include reduction of the nitro groups, acetylation of the amino groups and hydroxylation of the phenyl ring. Plants Metabolism in tobacco is rapid and extensive; reduction or complete removal of substituents occurs. Soil/Environment Strongly adsorbed and therefore immobile in soil; degradation is by photolysis. Stable to hydrolysis at pH 5, 7 and 9.