Cyromazine 灭蝇胺



通用名: Cyromazine
CAS NO.: 66215-27-8
化学名称: N-环丙基一1、3、5一三嗪一2、4、6一三胺
分子式:C6H10N6 分子量:166.2
理化性质: 白色或淡黄色固体,熔点:219-223℃,蒸气压>0.13mPa(20℃),20℃时比重为1.35g/cm3。溶解性(20℃):水11000mg/L(PH7.5),稍溶于甲醇和乙醇。310℃以下稳定,在PH5-9时,水解不明显,70℃以下28天内未观察到水解。
作用对象及特点: 本药剂为1,3,5 - 三嗪类昆虫生长调节剂,对双翅目幼虫有特殊活性,可以诱使双翅目幼虫和蛹在形态上发生畸变,成虫羽化不全或受抑制。用于控制动物厩舍内的苍蝇以及防治黄瓜、茄子、四季豆、叶菜类和花卉上的美洲斑潜蝇等农业害虫。
毒性: 大鼠急性经口LD50 3387mg/kg,大鼠急性经皮LD50 >3100mg/kg
指标: 指标 99%原药 75%可湿性粉剂 50%可湿性粉剂 10%水剂 50%可溶性粉剂
有效成份含量,% ≥99.0 ≥75.0 ≥50.0 ≥10.0 ≥50.0
水份,% ≤0.5 ≤3.0 ≤3.0 - ≤3.0
润湿时间,S - ≤60.0 ≤60.0 - -
悬浮率,% - ≥80.0 ≥80.0 - -
PH值范围 6.0-9.0 6.0-9.0 6.0-9.0 5.0-8.0 6.0-9.0
细度(通过44μm筛)% - ≥99.0 ≥99.0 - -
包装: 25、50公斤镀锌铁桶或纸板桶装,内衬塑料袋,或按客户要求。



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Common name cyromazine (BSI, draft E-ISO, (f) draft F-ISO, ANSI)
IUPAC name N-cyclopropyl-1,3,5-triazine-2,4,6-triamine
Chemical Abstracts name N-cyclopropyl-1,3,5-triazine-2,4,6-triamine
CAS RN [66215-27-8] Development codes CGA 72 662 (Ciba-Geigy) Official codes OMS 2014

Mol. wt. 166.2 M.f. C6H10N6 Form Colourless crystals. M.p. 224.9 °C V.p. 4.48 ´ 10-4 mPa (25 ºC) (OECD 104) KOW logP = -0.061 (pH 7.0) (OECD 107) Henry 5.8 ´ 10-9 Pa m3 mol-1 (calc.) S.g./density 1.35 (20 ºC) Solubility In water 13 g/l (OECD 105) (pH 7.1, 25 ºC). In methanol 22, isopropanol 2.5, acetone 1.7, n-octanol 1.2, dichloromethane 0.25, toluene 0.015, hexane 0.0002 (all in g/kg, 20 ºC). Stability Stable up to 310 ºC. Stable to hydrolysis for 28 days at up to 70 ºC. pKa 5.22, weak base

History Insect growth regulator reported by R. D. Hall et al. (J. Econ. Entomol., 1980, 73, 564) and by R. E. Williams et al. (Poultry Sci., 1980, 59, 2207). Introduced as an insecticide by Ciba-Geigy AG (now Syngenta AG). Patents GB 1587573; BE 857896 Manufacturers Gilmore; Sannong; Syngenta

Biochemistry Chitin synthesis inhibitor. Mode of action Insect growth regulator with contact action, which interferes with moulting and pupation. When used on plants, action is systemic: applied to the leaves, it exhibits a strong translaminar effect; applied to the soil, it is taken up by the roots and translocated acropetally. Uses Control of Diptera larvae in chicken manure by feeding to the poultry or treating the breeding sites. Also used to control flies on animals. Used as a foliar spray to control leaf miners (Liriomyza spp.) in vegetables (e.g. celery, melons, tomatoes, lettuce), mushrooms, potatoes and ornamentals, at 75-225 g/ha; also used at 190-450 g/ha in drench or drip irrigation. Formulation types SL; WP. Selected products: 'Trigard' (plant protection) (Syngenta); 'Cyclon' (Cequisa); 'Genialroc' (Rocca); 'Gilzine' (Gilmore); 'Neporex' (veterinary use) (Novartis A H); 'Trivap' (Vapco); 'Vetrazin' (veterinary use) (Novartis A H)

'Armor' (Syngenta); 'Citation' (Syngenta); 'Larvadex' (Syngenta); 'Patron' (Syngenta)

Product analysis by hplc. Residues determined by glc or hplc. Details available from Syngenta.

Reviews FAO/WHO 59, 61 (see part 2 of the Bibliography). Oral Acute oral LD50 for rats 3387 mg/kg. Skin and eye Acute percutaneous LD50 for rats >3100 mg/kg. Mild skin irritant; non-irritating to eyes (rabbits). Inhalation LC50 (4 h) for rats >2.720 mg/l air. NOEL (2 y) for rats 300, mice 1000 mg/kg diet. ADI (JMPR) 0.02 mg/kg b.w. [1990]. Toxicity class WHO (a.i.) U; EPA (formulation) III

Birds Acute oral LD50 for bobwhite quail 1785, Japanese quail 2338, Pekin ducks >1000, mallard ducks >2510 mg/kg. Fish LC50 (96 h) for bluegill sunfish >90, carp, catfish and rainbow trout >100 mg/l. Daphnia LC50 (48 h) >9.1 mg/l. Algae LC50 124 mg/l. Bees Non-toxic to adult honeybees (no contact action up to 5 mg/bee). Worms LC50 >1000 mg/kg. Other beneficial spp. Non-toxic.

Animals In rats, cyromazine is efficiently excreted, mainly as the parent compound. Plants Rapidly metabolised in plants. The principal metabolite is melamine. Soil/Environment Cyromazine and its main metabolite melamine are moderately mobile. Numerous studies conducted (laboratory and field) demonstrate that cyromazine is efficiently degraded by biological mechanisms.