Cyflufenamid 环氟苄酰胺环氧菌胺

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环氟菌胺：

CAS号: 180409-60-3
英文名称: CYFLUFENAMID
英文同义词: nf-149;CYFLUFENAMID;CYFLUFENAMID STANDARD;cyflufenamid (bsi, pa iso)
中文名称: 环氟菌胺
中文同义词: 环氟菌胺
分子式: C20H17F5N2O2
分子量: 412.35

密度 1.366g/cm3
沸点 457.394°C at 760 mmHg
闪点 230.424°C
蒸汽压 0mmHg at 25°C
物化性质储存条件：0-6℃

制剂主要剂型有两种：单剂EW50g／L，混剂18.5％WDG（环氟菌胺＋氟菌唑）。
作用机理环氟菌胺通过抑制白粉病菌生活史（也即发病过程）中菌丝上分生的吸器的形成和生长，次生菌丝的生长和附着器的形成。但对孢子萌发、芽管的廷长和附着器形成均无作用。尽管如此，其生物化学方面的作用机理还不清楚，正在研究中。试验结果表明环氟菌胺与吗啉类、三唑类、苯并咪唑类、嘧啶胺类杀菌剂、饯粒体呼吸抑制剂、苯氦喹啉等无交互抗性。

应用
室内保护活性试验结果表明对小麦、黄瓜、草莓、苹果、葡萄白粉病的EC75（mg／L）分别为0.2、0.2、0.2、0.8、0.8。
大量的生物活性测定结果表明，环氟菌胺对众多的白粉病不仅具优异的保护和治疗活性，而且具有很好的持效活性和耐雨水冲刷活性。尽管其具有裉好的蒸气活性和叶面扩散活性，但在植物体内的移动活性则比较差，即内吸活性差。环氟茵胺对作物安全。
大田药效结果表明环氟菌胺推荐使用剂量为25g（a.i.）／hm2；在此剂量下，环氟菌胺对小麦白粉的保护和治疗防效大于90％，优于苯氧喹啉（qulnoxyfen）150g（a.i.）／hm2、丁苯吗啉（fenproPlmorph）750g（a.i.／hm2的防效，且增产效果明显。试验结果还表明环氟菌胺与目前使用的众多杀茵剂无交互抗性。试验结果还表明18.5％WDG（环氟菌胺＋氟菌唑）的活性明显优于单剂。

环氟菌胺：

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cyflufenamid
Fungicide

Cyflufenamid

NOMENCLATURE
Common name cyflufenamid (BSI, pa ISO)
IUPAC name (Z)-N-[a-(cyclopropylmethoxyimino)-2,3-difluoro-6-(trifluoromethyl)benzyl]-2-phenylacetamide
Chemical Abstracts name (Z)-N-[[(cyclopropylmethoxy)amino][2,3-difluoro-6-(trifluoromethyl)phenyl]methylene]benzeneacetamide
CAS RN [180409-60-3] Development codes NF-149

PHYSICAL CHEMISTRY
Mol. wt. 412.4 M.f. C20H17F5N2O2 Form White solid with a slight aromatic odour. M.p. 61.5-62.5 °C B.p. 256.8 °C V.p. 3.54 ´ 10-2 mPa (20 ºC, gas saturation method) KOW logP = 4.70 (pH 6.75, 25 ºC) S.g./density 1.347 (20 °C) Solubility In water 5.20 ´ 10-4 g/l (pH 6.5, 20 ºC). In dichloromethane 902, acetone 920, xylene 658, acetonitrile 943, methanol 653, ethanol 500, ethyl acetate 808, n-hexane 18.6, n-heptane 15.7 (all in g/l, 20 ºC). Stability Stable at pH 4 and 7; DT50 288 d (pH9). Aqueous photolysis DT50 594 d. pKa 12.08

COMMERCIALISATION
Patents US 5847005; WO96/19442 Manufacturers Nippon Soda

APPLICATIONS
Mode of action Fungicide with pre- and post-emergence activity. Uses Registered for control of powdery mildew in wheat, top fruit and vegetables, at 2.5 g/100l, in Japan. Under development for control of powdery mildew in wheat and barley, at 25 g/ha, in Europe. Formulation types WG; EW. Selected products: 'Pancho' (Nippon Soda); mixtures: 'Pancho TF' (+ triflumizole) (Nippon Soda)

MAMMALIAN TOXICOLOGY
Oral Acute oral LD50 for male and female rats >5000 mg/kg. Skin and eye Acute percutaneous LD50 for male and female rats >2000 mg/kg. Weakly irritating to eyes, non-irritating to skin (rabbits). Inhalation LC50 (4 h) for male and female rats >4.76 mg/l. ADI 0.041 mg/kg (Japan).

ECOTOXICOLOGY
Birds Acute oral LD50 for bobwhite quail >2000 mg/kg. Dietary LC50 for bobwhite quail >5000 ppm. Fish LC50 (96 h) for carp >1.14 ppm. Daphnia LC50 (48 h) >1.73 ppm. Algae EbC50 (72 h) for Selenastrum capricornutum >0.828 ppm; ErC50 (72 h) for Selenastrum capricornutum >0.828 ppm. Bees LD50 (oral and contact) >100 mg/bee. Worms LC50 for earthworm >1000 mg/kg soil. Other beneficial spp. No effect on Orius similis at 50ppm.

Cyflufenamid 环氟苄酰胺 环氧菌胺

Cyflufenamid 环氟苄酰胺环氧菌胺