Cadusafos 硫线磷

硫线磷

简介
英文通用名 cadusafos
分子式 C10H28O2PS2 相对分子质量 270.4
其他名称 克线丹，Rugby，sebufos
性状 原药为淡黄色透明液体，b.p.122～114℃/107pa，相对密度1.054（20℃），蒸气压012Pa(25℃)，闪点129.4℃。可与大多数有机溶剂完全混溶，水中溶解度0.25g/L。对光，热稳定。
毒性 属于高毒杀线虫剂。原油大鼠急性经口LD50为37.1mg/kg，大鼠急性吸入LC50为0.0329mg/L，兔急性经皮LD50为24.4mg/kg(雄)和41.8mg/kg(雌)。对眼睛有轻微刺激作用，对皮肤无刺激作用。在试验剂量下无致癌、致畸、致突变作用。对鸟类和鱼类有毒。
剂型 10%颗粒剂，250g/L硫线磷乳油。
特点 触杀性的杀线虫剂，无熏蒸作用，水溶性及土壤移动性较低，在沙壤土和粘土中半衰期为40-60天。是一种胆碱酯酶抑制剂。是当前较理想的杀线虫剂。
适用范围 适于防治柑橘、菠萝、咖啡、香蕉、花生、甘蔗、蔬菜、烟草及麻类作物线虫。

使用方法
1. 花生线虫防治 每亩用10%颗粒剂1500-3000g，可以沟施后播种，或随施随种，或进行15-25cm宽的混土带施药。
2. 香蕉线虫防治 每丛用10%颗粒剂20-30g，8个月施药1次。先将其周围表土3-5cm深疏松，把药均匀撒在距香蕉假茎30-50cm以内土中，然后覆土。
3. 甘蔗田线虫防治 每亩用10%颗粒剂3000-4000g，种植时在蔗畦两侧开沟施药。
4. 柑橘线虫防治 用量同甘蔗田。先把树冠下的表土3-5cm疏松，均匀撒施随即覆土。
5. 麻类线虫防治 每亩用10%颗粒剂3000-4000g，施用方法同花生地。
注意事项
1. 搬运或施药时要穿戴防护用具，完毕后用肥皂水或清水冲洗。
2. 贮存在远离粮食、饲料及儿童能够行到的地方。
3. 如误服应立即喝水、催吐，若病人身上青紫，可静脉注射阿托品同时用解毒剂2-PAM。

cadusafos
Nematicide, insecticide
IRAC 1B; organophosphate

NOMENCLATURE
Common name cadusafos (BSI, draft E-ISO, ANSI)
IUPAC name S,S-di-sec-butyl O-ethyl phosphorodithioate
Chemical Abstracts name O-ethyl S,S-bis(1-methylpropyl) phosphorodithioate
Other names ebufos* (rejected common name proposal) CAS RN [95465-99-9] Development codes FMC 67 825

PHYSICAL CHEMISTRY
Mol. wt. 270.4 M.f. C10H23O2PS2 Form Colourless to yellow liquid. B.p. 112-114 ºC/0.8 mmHg V.p. 1.2 ´ 102 mPa (25 ºC) KOW logP = 3.9 S.g./density 1.054 (20 ºC) Solubility In water 248 mg/l. Completely miscible with acetone, acetonitrile, dichloromethane, ethyl acetate, toluene, methanol, isopropanol, and heptane. Stability Stable up to 50 ºC. Half-life in light <115 d. F.p. 129.4 ºC (Seta closed cup)

COMMERCIALISATION
History Nematicide and insecticide discovered by FMC Corp. Manufacturers FMC

APPLICATIONS
Biochemistry Cholinesterase inhibitor. Mode of action Contact and stomach action. Uses Controls various nematodes and larvae of Noctuidae, Agriotes spp. and other soil insects in bananas, citrus, maize, potatoes, sugar cane, tobacco and vegetables, at 3-10 kg/ha. Formulation types EW; GR. Selected products: 'Apache' (FMC); 'Rugby' (FMC)

OTHER PRODUCTS
Discontinued products: 'Taredan' * (FMC)

ANALYSIS
Product analysis by glc. Residues determined by glc with FID. Details available from FMC Corp.

MAMMALIAN TOXICOLOGY
Reviews FAO/WHO 62, 64 (see part 2 of the Bibliography). Oral Acute oral LD50 for rats 37.1, mice 71.4 mg tech./kg. Skin and eye Acute percutaneous LD50 for male rabbits 24.4, female rabbits 41.8 mg/kg. Non-irritating to skin and practically non-irritating to eyes of rabbits. Inhalation LC50 (4 h) for rats 0.026 mg/l air. NOEL (2 y) for rats 1 mg/kg diet; (1 y) for male dogs 0.001, female dogs 0.005 mg/kg daily. In oncogenicity tests (2 y), male mice 0.5, female mice 1 mg/kg diet. ADI (JMPR) 0.0003 mg/kg [1991]. Toxicity class WHO (a.i.) Ib; EPA (formulation) III

ECOTOXICOLOGY
Birds Acute oral LD50 for bobwhite quail 16, mallard ducks 230 mg/kg. Fish LC50 (96 h) for rainbow trout 0.13, bluegill sunfish 0.17 mg/l. Daphnia LC50 (48 h) 1.6 mg/l. Algae EC50 (96 h) 5.3 mg/l. Worms LC50 (14 d) for Eisenia foetida 72 mg/kg.

ENVIRONMENTAL FATE
EHC 63 (WHO, 1986; a general review of organophosphorus insecticides). Animals Readily absorbed, metabolised and eliminated in urine and faeces. Hydroxy sulfones were the major metabolites, followed by phosphorothioic and sulfonic acids. Soil/Environment DT50 in silty clay, sandy loam soils 11-55 d. Koc 144-351.